So many symptoms come with long term Celiac Disease.  This is because there will be  any symptom  that can develop from extensive nutritional deficiencies.  These symptoms, which are vast and varied, affect people physically, mentally and emotionally.  To understand this better please read Why is Gluten a Problem, as well as Wheat Allergy vs. Celiac Disease.

Some of these symptoms can be, but are not limited to:

Neurological: central and peripheral nervous system impairment, numbness and tingling, neuropathy.

Mental: memory loss, confusion, depression, irritability

Emotional:  depression; irritability, can lead to a diagnosis of many psychological disorders; although there are no definitive links, Autistic children, almost unanimously, benefit from a gluten free diet.

Physical: fatigue; weight loss; nutritional deficiencies; stomach upset; nausea, gas, bloating, foul smelling feces, constipation, diarrhea, gastric ulcers;  headaches;  anemia;  eczema, psoriasis or dermatitis herpetiformis; joint and or bone pains; muscle cramps and wasting.